SanDermin®-Clear skin the easy way
SanDermin® capsules are a preparation for the dietary treatment of uncomplicated skin infections such as acne vulgaris. The active ingredients are the naturally occurring components lactoferrin and zinc
Active ingredients and application notes
1 capsule SanDermin® contains:
Lactoferrin 200 mg
Zink 6 mg (=60% RDA)
Adults and children over the age of 10 take 1 capsule of SanDermin® per day. Take the capsule with plenty of fluid before or at mealtime. In case of difficulty swallowing the capsule, it can also be opened and the contents consumed in (not hot) food and drink.
Advantages of SanDermin®
- No antibiotic, no resistance
- No side effects
- Suitable for longer-term use
- Also in pregnant women, breastfeeding, adolescents
- Can be combined with other local or systemic acne therapies
- No interaction with contraceptives
- Only 1 capsule daily, thus improved compliance
- Free from lactose, sugar, gluten and dyes, thus better tolerance.
Package size: 28 pieces (lasts one month).
Acne vulgaris (acne) is the most common skin disorder in adolescence, but may also be a problem for adult women, whereas men are usually less affected by acne after adolescence.
The pathogenesis of acne is multifactorial and complex. Acne is a skin disease that occurs primarily on the face and on the chest and back. Blackheads are formed through increased sebum production and a cornification disorder in the sebaceous follicle. In addition, if bacteria (for example, Propionibacterium acnes) colonize, the blackheads become inflamed, resulting in pimples, reddened nodules (papules), pustules (pustules), encapsulated small collections of pus (abscesses) or painful lumps. In the further course, fluid-filled, encapsulated cavities in the tissue (cysts) and scars can also occur. Especially in puberty, many adolescents are affected by blackheads, pimples and inflammation - the common acne (acne vulgaris).
The active ingredient of SanDermin® capsules is the protein lactoferrin, an iron-binding glycoprotein found in colostrum, milk, and many body secretions and cells of most mammalian species. Lactoferrin is an important component of the innate immune system in humans and animals and is known for many biological activities, such as antimicrobial, antioxidant, anti-inflammatory and immunoregulatory properties (Pan et al., 2007).
Both intact lactoferrin as well as partially hydrolyzed lactoferrin (lactoferricin) can kill bacteria, viruses and fungi. Hydrolyzed lactoferrin (e.g., lactoferricin) is produced by proteolytic cleavage (by pepsin in the stomach) of a portion of the lactoferrin molecule. This observation is relevant for the oral administration of lactoferrin because these degradation products often have significantly higher antimicrobial activity than the parent compound (Bruni et al 2016, Sijbrandij et al., 2017).
3-fold effect of lactoferrin against acne
Lactoferrin shows immunomodulatory and antiinflammatory activity and is lowering skin lipid levels. There is some evidence that lactoferrin, as a component of normal skin, plays a role in the regulation of the cutaneous immune function (Cumberbatch 2000). Due to the action of lactoferrin, prolonged oral lactoferrin administration, together with zinc, reduces sebum production and reduces inflammatory lesions (Kim et al., 2010).
Lactoferrin is an integral part of the innate immune system. It is also found in exocrine secretions and in immune cells (neutrophil granulocytes). Many publications report antimicrobial and anti-inflammatory activity of lactoferrin, which is therefore of substantial importance in preventing infection and inhibiting inflammation.
The mechanism by which lactoferrin exerts its antimicrobial and antiviral activity in vivo is laborious and in many cases not fully understood. Two basic biochemical properties of lactoferrin contribute to its defensive action against bacteria, viruses and some fungi: the high iron-binding capacity and the strong interaction with other molecules and surfaces. The antimicrobial effect comes from a direct bacteriostatic and bactericidal activity on the one hand, and is helped by the activation of reactions that provoke a protective immune response after infection (Weinberg 2007, Roseanu et al., 2010).
Among other properties, Lactoferrin also shows an anti-inflammatory activity. It could be shown that an inflammatory reaction due to a viral infection can be slowed down by the inhibition of cytokine syntheses, for example by a blockade of receptors (Zheng et al., 2014). Orally ingested lactoferrin also has the property of reducing interleukin-1beta (IL-1ß) in the skin, thus it has an anti-inflammatory effect and can prevent damage caused by long-lasting inflammatory processes in the skin (Drago-Serrano et al ).
Effect on skin lipids
In addition to its antimicrobial and anti-inflammatory activity, Lactoferrin (the active ingredient of SanDermin® capsules) also has an effect on skin lipids. It has been shown that when lactoferrin is administered to acne patients, sebum production is reduced by about one third (Kim et al., 2010).
Zinc in SanDermin® capsules has antibacterial, anti-inflammatory and anti-sebum properties and has been shown to be effective against mild to moderate acne. In combination with lactoferrin, this results in a synergistic effect on acne while maintaining the good tolerability of the preparation (Brandt 2013).
Lactoferrin together with zinc combines the action against bacteria, viruses and some fungi with an anti-inflammatory activity and an effect on skin lipids. It is therefore suitable for use against infectious-inflammatory events in dermatology, such as acne.
SanDermin® capsules are a new, well-tolerated systemic therapy option in the treatment of acne, which, together with topical preparations, provides a satisfactory result for the treatment of mild to moderate acne.